Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: Implications in lipid metabolic disorders
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چکیده
منابع مشابه
AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N6-methyladenosine
Skeletal muscle plays important roles in whole-body energy homeostasis. Excessive skeletal muscle lipid accumulation is associated with some metabolic diseases such as obesity and Type 2 Diabetes. The energy sensor AMPK (AMP-activated protein kinase) is a key regulator of skeletal muscle lipid metabolism, but the precise regulatory mechanism remains to be elucidated. Here, we provide a novel me...
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SUMMARY Due to the importance of coronary heart diseases in today's world and in view of the fact that hyperlipidemia, hyperglycemia and obesity are regarded as the main risk factors in these diseases and also considering the paucity of epidemiologic surveys in our society, this study was carried out in Islamshahr 30 Km to the southwest of Tehran. Out of 244000 population of the area, 2033 per...
متن کاملMeclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5
Two human demethylases, the fat mass and obesity-associated (FTO) enzyme and ALKBH5, oxidatively demethylate abundant N(6)-methyladenosine (m(6)A) residues in mRNA. Achieving a method for selective inhibition of FTO over ALKBH5 remains a challenge, however. Here, we have identified meclofenamic acid (MA) as a highly selective inhibitor of FTO. MA is a non-steroidal, anti-inflammatory drug that ...
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MicroRNAs regulating lipid metabolism in atherogenesis.
MicroRNAs have emerged as important post-transcriptional regulators of lipid metabolism, and represent a new class of targets for therapeutic intervention. Recently, microRNA-33a and b (miR-33a/b) were discovered as key regulators of metabolic programs including cholesterol and fatty acid homeostasis. These intronic microRNAs are embedded in the sterol response element binding protein genes, S...
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ژورنال
عنوان ژورنال: Genes & Diseases
سال: 2021
ISSN: 2352-3042
DOI: 10.1016/j.gendis.2021.01.005